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Infographic: Landmark trials in Neuro-Ophthalmologyresults of the phase II Idiopathic Intracranial Hypertension Pressure Trial
Figure 1B)
Thus, as is the case in animal cells (Bernardo et al., 2003), it is now thought that fungal uptake of gliotoxin results in GSH-mediated chemical reduction of the gliotoxin disulfide to yield DTG, which not only can lead to GSH depletion but strongly suggests that gliotoxin-mediated intracellular cytotoxicity is dependent on GSH presence
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