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A binomial logistic model was fitted to age, sex, and inclusion date using treatment group as the dependent variable ( We matched subjects 1:1 on the logit transformation of the propensity score by nearest-neighbor (greedy) matching without replacement, using a caliper width equal to 0.2 x the (pooled) SD of the transformed propensity scores ( For multiple imputed datasets, matching and statistical analyses were performed separately on each resultant dataset, and the statistical estimates were finally pooled

For this article, best is evaluated across five criteria that matter to real people pursuing real fat loss outcomes: Total body weight reduction: The percentage of baseline body weight lost over a standardized time period

A recent JAMA Network Open analysis found the vast majority of people quit taking these drugs within two yearssuch stops in treatment often reverses weight loss and health gains

Tirzepatide tends to be more expensive: As a newer dualhormone therapy, it typically comes with a higher price point and stricter requirements for insurance approval