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Continued investigation is necessary to further clarify mechanistic interactions and signaling dynamics
Co-treatment of larvae with 6-AH and Dihexa completely attenuates the hair cell protection conferred by Dihexa treatment (Figure 5B)
Among emerging CKD-protective treatments, finerenone was approved by the FDA in 2021 and was also recommended in the 2022 KDIGO guidelines as first-line therapy for patients with type 2 diabetes who are at high risk of kidney disease progression and cardiovascular events [6, 15]
This early response involves proximal small-intestinal L-cells alongside neural and hormonal signals, including vagal nerve activation and the release of gastric hormones
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![Mechanism of action of GLP-1 [25]](https://www.researchgate.net/publication/256289222/figure/fig1/AS:614177232142337@1523442671231/Mechanism-of-action-of-GLP-1-25.png)
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