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The chosen specificity effectively reduced IgG recycling in cells and the IgG plasma half-life in relevant human transgenic mice and NHPs both as a full-length IgG4 and as other monovalent Fab-containing molecules [124]
NIH/3T3 cells were stained with 0.5 M Calcein-AM and the fluorescence was detected by CLSM
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The compounds could potentially be combined, as their mechanisms do not overlap
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