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The expressions of each protein in colon tissues were captured by optical microscope (magnification, 200 for colon tissues)

6 GLP-1 RAs exhibit significant nephroprotective effects, including reducing albuminuria, improving renal haemodynamics and attenuating oxidative stress and inflammation in the kidneys

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Dysregulation of BAs receptor and metabolite-mediated signaling axes is increasingly implicated in the pathogenesis of inflammatory bowel disease, bile acid malabsorption, diarrhea-predominant irritable bowel syndrome, colorectal cancervia DNA damage and Wnt/ -catenin pathway activationand systemic conditions such as obesity, non-alcoholic fatty liver disease, and sepsis-related intestinal injury