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A possible explanation for these conflicting results is that GIPR is subject to less desensitization than GLP-1R
Out of the current antidiabetic medications, 2.4 mg semaglutide OW is the only one approved for the treatment of MASH by FDA Phase 3 trials with tirzepatide and dual GLP-1/glucagon agonist survodutide are ongoing Many other GLP-1-based emerging medications such as cagrilintide/semaglutide, triple GLP-1/GIP/glucagon agonist retatrutide, small non-peptide GLP-1 agonist orforglipron and many others may also have a great potential to improve MASLD or MASH Based on the excellent review paper by Scott Isaacs, MD, FACP, FACE and colleagues published in Frontline Gastroenterology #mash #mafld #antidiabeticmedication #semaglutide #tirzepatide #survodutide #pioglitazone #insulin #metformin #cvcomplications To view or add a comment, sign in TL;DR microdosing psilocybin may treat diabetes *in mice A new study in the journal Pharmacological Research showed that low-dose psilocybin reduced body-weight gain, liver steatosis, hyperglycaemia, and insulin resistance without eliciting central nervous system effects
GH pulse shape and IGF-1 response are what drive most downstream physiology, and neither peptide has published long-term human outcome data for body composition, strength, or longevity endpoints
