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The core pathology of type 2 diabetes is insulin resistance and beta cell failure, which leads to imbalance of energy distribution: reduced glucose uptake by muscle and adipose tissue, increased gluconeogenesis in liver, and increased glucose and free fatty acid (FFA) levels in blood
2010 Jun 28;13(3):98100
If you notice a site consistently causes more irritation than others, mention it at your next check-in, since some patients have body composition factors that make certain sites less ideal for them
doi: 10.1016/j.neuron.2019.01.056 9 BennettB
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