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Absorption, metabolism and excretion of semaglutide in humans and nonclinical species
Diabetes 58(4):975983
Uncertainty around prepregnancy GLP-1 benefits The use of GLP-1 RAs before pregnancy, followed by discontinuation, was associated with a mean gestational weight gain of 3.3 kg compared to unexposed women
This is particularly challenging for peptide-based biologics like glucagon-like peptide-1 (GLP-1), which have low circulating levels and require high sensitivity in complex biological matrices
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