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Signs of significant dehydration that you cannot correct with fluids, or a sustained heart rate jump well beyond the expected range, also warrant a conversation
(92) and more recently Heinla et al
However, there was significant variation in estimated CATE among people, with the BCF model indicating a mean glycemic advantage on SGLT2 inhibitor treatment for 48% (n=13,110) of participants and on the glucagaon-like-peptide-1 receptor agonist treatment for 52% (n=14,209) of individuals
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