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Based on the 2026 Clinical Obesity review of 480,825 adults, the most commonly deficient nutrients in GLP-1 users are vitamin D (13.6% deficient by 12 months), iron (2630% lower ferritin than comparators), calcium, and B12
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Whilst semaglutide does not typically cause cognitive impairment, patients taking both medications should be monitored for any changes in mental function, particularly if topiramate doses are increased
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