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Short-acting GLP-1RAs, such as exenatide and lixisenatide, have a half-life of 24 h, requiring daily administration once or twice a day

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Retatrutide targets GLP1 + GIP + glucagon, so some commentators have started calling it GLP3 to suggest a thirdgeneration medication. How Retatrutide Works: Triple Agonist Mechanism Retatrutide is being developed as a onceweekly injectable that activates GLP1, GIP, and glucagon receptors at the same time to influence appetite, blood sugar, and energy expenditure. GLP1 receptor activation Reduces appetite and food intake

For instance, research has shown that low levels of serum IGF-1 are associated with impaired glucose tolerance and an increased risk of type 2 diabetes