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Key Facts A trial of 195 adults with obesity found that glucagon-like peptide-1 (GLP-1) receptor agonists, a class of drugs used to treat diabetes, resulted in reduced hip and spine bone mineral density when used without exercise compared to a placebo or exercise alone, researchers said

This three-phase randomized controlled clinical trial involves 1961 overweight or obese adults (none of them suffering from diabetes, average weight 105 kg, average body mass index 38 kg/m2), the clinical trial was conducted at 129 sites in 16 countries in Asia, Europe, and North and South America

This could cause adverse reactions, and that raised a red flag

Rimonabant , a fascinating drug Walker describes as "anti-marijuana" or an "anti-munchies drug," worked as an inverse agonist of the cannabinoid receptor but was withdrawn due to severe cognitive side effects