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Tirzepatide (Zepbound): The Next Generation of Weight Loss Medicine Tirzepatide, sold under the brand name Zepbound for weight management, represents the next evolutionary step beyond standard GLP-1 therapy
Current UK professional guidance emphasises: Patients should inform their surgical team and anaesthetist that they are taking a GLP-1 medication as soon as surgery is planned Healthcare professionals should specifically ask about GLP-1 use during preoperative assessment, as patients may not recognise these medications as relevant to their surgery The decision to continue or pause GLP-1 therapy should be made on an individual risk-based assessment , considering the type of surgery, the specific GLP-1 agent, dose escalation status, presence of gastrointestinal symptoms, and the patient's clinical circumstances Many patients can safely continue GLP-1 medications perioperatively with appropriate precautions, while those at higher risk may benefit from temporary cessation The Summary of Product Characteristics (SmPC) for GLP-1 medications notes the delayed gastric emptying effect, which anaesthetists consider when planning perioperative care
The serious side effects such as pancreatitis and kidney issues are rare across all options
If something isnt working or if a concern arises the protocol changes
