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GLP-1 receptors are expressed in pancreatic islet cells, the gastrointestinal tract, vagal afferents, and brain regions involved in satiety and energy balance
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This epigenetic regulation upregulates NLRP3 inflammasome activity, which subsequently triggers tubular cell pyroptosis, thereby exacerbating tubular damage and the progression of DKD (166)
True copper allergy typically produces hives, swelling, or systemic symptoms beyond localized skin changes
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