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Lean mass stabilized between months 712, with an overall ~3 kg loss
Amylins physiological roles include inhibition of glucagon secretion, reduction in food intake, delay in gastric emptying, activation of brown adipose tissue via the sympathetic nervous system, and increased energy expenditure, ultimately leading to decreased blood glucose levels and weight loss [95]
At the same time, increased expression of BBD and OCTN2 also plays a role in regulating carnitine homeostasis by stimulating the intake and biosynthesis of the carnitine, thus increasing the concentration of carnitine (86)
One probable interpretation is that transport of molecules across the BBB is highly controlled and the ingestion of the abnormally high doses of drug may affect this
