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An argument for reduced dosing frequency of GLP-1s to maintain long-term weight loss , based on mathematical modeling : Switching semaglutide from 1x/week to 1x/2 weeks = 50% fewer doses but 72% of weight loss retained 1x/month may preserve ~50% of weight loss Caveat: based on simulations we need real-world data to support this hypothesis

Pharmacokinetics and clinical implications of semaglutide: a new glucagon-like peptide (GLP)-1 receptor agonist

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Hydroxytyrosol prevents diet-induced metabolic syndrome and attenuates mitochondrial abnormalities in obese mice