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This incretin effect is considerably attenuated in people with type 2 diabetes (see Figure 1), a loss that is even considered an early indicator of the disease, but it was observed that this deficit could be completely corrected by the continuous infusion of GLP-1 to diabetic patients
IGF-I is involved in neuronal myoblast proliferation and differentiation, and organ development
[1] It is important to note that the FDA has not yet approved GLP-1 agonists for treating type 1 diabetes, but some healthcare providers may prescribe them off-label
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