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However, during high-fat diet (HFD) feeding, obesity and insulin resistance, the accumulation of medium-chain and long-chain acylcarnitines due to incomplete -oxidation may negatively regulate the expression of nuclear-encoded mitochondrial genes, further reducing mitochondrial number and function and creating a vicious metabolic cycle [33]
However, l-carnitine is actually an amino acid that exists in the body naturally
Mol Cell Neurosci (2016) 70:6875
B., Nuhoho, S., Ali, S
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