Landmark studies include STEP for semaglutide (NEJM, 2021), SURMOUNT for tirzepatide (NEJM, 2022), and SURMOUNT-OSA for tirzepatide in obstructive sleep apnea (NEJM, 2024)
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That peak, called Cmax, is when side effects are most intense
Participants saw improvements in blood pressure, blood sugar, insulin and cholesterol levels, with many reverting from prediabetes to normal blood sugar levels
