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HIF-1 has been shown to enhance the expression of fatty acid synthase (FASN), which catalyzes the synthesis of long-chain fatty acids from acetyl-CoA and malonyl-CoA (113)
As patients lose weight and experience reduced pain, they often become more active
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Published literature repeatedly references interactions involving nitric oxide pathways, angiogenic signaling, fibroblast activity, collagen organization, endothelial repair, oxidative stress modulation, and neurotransmitter systems
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