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19 Early studies: There were studies in the 1950s and the1960s that showed that oral vitamin B 12 could be absorbed by patients with pernicious anemia and could lead to resolution of the anemia
The risk of CV mortality increases with increased CKD staging, regardless of diabetes status
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Additionally, proteolytic degradation is a major challenge in peptide-based therapeutics, as it results in short half-life, low bioavailability, rapid clearance, and ultimately reduced therapeutic efficacy
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