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Some diabetes medications, particularly sulfonylureas and sodium-glucose cotransporter-2 inhibitors, may increase the risk of low blood sugar when combined with semaglutide, requiring dose adjustments or closer monitoring
These agents act through multiple mechanisms, including direct cardioprotection, vasodilation, natriuresis, weight reduction, lipid profile improvement, anti-inflammatory effects, renal protection, reduction in plaque formation, and neurohormonal regulation
Insomnia is not listed among common adverse reactions in FDA prescribing information for Mounjaro or Zepbound, and clinical trials did not identify it as a statistically significant side effect
In one study, at a maximum dose of 15 mg per week, tirzepatide led to a weight loss of about 20% after one year
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