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Particularly, PARP14 can promote glycolysis in different tumor models, such as human hepatocellular carcinoma (HCC), by maintaining reduced PKM2 activity ( Deregulation of LncRNAs and microRNAs (long and short non-coding RNAs, respectively), considered epigenetic regulators, contributes to therapeutic resistance through the regulation of energy metabolism ( Particularly in K562 cells, the expression level of miR-18a-5p in DOX-resistant cells is lower compared to K562 cells and normal lymphocytes, and strikingly, miR-18a-5p can inhibit the expression of HIF-1 and, in turn, induce a reduction in the production of pyruvate, ATP and affect the expression of GLUT1, HK-II, PKM2, and lactate dehydrogenase A (LDHA) ( 2.3 Regulation of increased glycolytic flux: extrinsic mechanistic factors In the bone marrow microenvironment, there are cellular and non-cellular components that influence the metabolic reprogramming of leukemia cells and can be considered external factors ( On the other hand, the Warburg effect implies an increase in the production of lactic acid and, therefore, an acidic microenvironment
They proposed the term ferroptosis to describe a new mode of regulated death distinct from apoptosis, autophagy and necrosis, characterized by lipid peroxidation dependent on iron [11]
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Dautres molcules sans toxine peuvent aussi dclencher des senseurs et mettre en marche lappareil cellulaire, dont bon nombre de nutriments de source vgtale
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