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Semaglutide carries the most extensive clinical trial history of the three, including the previously cited 68-week trial reporting average weight reductions exceeding 14%, which makes it a common reference point for metabolic and receptor-signaling studies
The most common version is 12.5 mg retatrutide + 2.5 mg cagrilintide in one 15 mg vial
Some small studies have explored its role in the treatment of withdrawal symptoms, particularly in reducing alcohol or opioid dependence
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