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The majority of patients were White (93%) and 54% were male

Increasing while nausea, vomiting or diarrhoea are unresolved reliably worsens them, and the most common consequence is that the patient abandons treatment altogether

The current evidence base points to several overlapping molecular pathways operating in parallel: VEGFR2/Akt/eNOS Angiogenic Signalling A primary mechanistic axis involves upregulation of vascular endothelial growth factor receptor 2 (VEGFR2), leading to activation of the Akt/eNOS (endothelial nitric oxide synthase) downstream pathway

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