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Generic semaglutide, a glucagon-like peptide-1 receptor agonist (GLP-1RA), has recently become available in Canada after regulatory exclusivity for semaglutide expired in Canada in January 2026years earlier than expected in the US and countries in Europe
This comparison examines whether retatrutide's triple agonist mechanism offers clinically meaningful advantages over semaglutide's proven single-agonist approach, while acknowledging the fundamental asymmetry in evidence quality between a fully approved drug and an investigational compound
At its highest dose, 36 mg, participants in a phase 3 trial lost an average of 12.4 percent of their starting weight over 72 weeks
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