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To further analyze the binding mode of COP1, we examined its interaction with Trib1 (PDB: 5IGQ) 43 , where COP1 residues from the top surface of the WD40 domain bind to Trib1 (residues V358-P359) through the bonding between Q356 sits in the binding pocket formed by S425, F645 and W517
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Too much fiber in a single meal creates gas, bloating, and discomfort that compounds the GI effects of the medication
Medication adherence issues can substantially impair effectiveness
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