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In line with the latter, GLP-1 have been shown to protect from ischaemia/reperfusion injuries in isolated perfused rat hearts ( It should be noted that one of the two major DPP-IV-generated truncated forms of GLP-1 (GLP-1 [9-36amide]) has been shown to have direct beneficial cardiac effects in mice, which is representative of the hypothesis that a GLP-1R-associated response can be elicited also by these metabolites and thus not only via the classic incretin pathway (Mller et al., 2019)
To move beyond correlation toward causality, large-scale, longitudinal, and mechanistic studies integrating multi-omics approaches including metagenomics, metabolomics, transcriptomics, and immunophenotyping are needed
But the comparison gets more interesting when you look at what each drug does during that time
Always consult with a qualified healthcare provider before starting any new medication or treatment plan
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