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Temporary holding of GLP-1 RAs is controversial, as it is unsupported by data regarding optimal washout for return of normal gastric emptying and could increase the risk of glycemic instability [12]

Opponents emphasized that demand does not replace controlled evidence and that adding substances to a federal list could be mistaken for an FDA endorsement

In focus: Semaglutide and GLP-1 Patent Filings This momentum followed earlier milestones in the companys insulin portfolio, including FDA approvals for Tresiba and Ryzodeg in 2015 and expanded use of Tresiba in children by 2016

Review any medication changes that coincided with apparent efficacy loss