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Intact glutathione is poorly membrane-permeant and extracellular glutathione is degraded by gamma-glutamyl transpeptidase before its amino acids are reimported (Zhang, Forman and Choi, Methods in Enzymology, 2005), whereas cysteine-delivery agents bypass that step

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Since NAC serves as a precursor to glutathione, supplementing with both can help elevate glutathione levels more effectively, enhancing its antioxidant effects and supporting overall detoxification processes