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This iron-sequestering capability is particularly important because excess free iron directly enters cells, concentrates in mitochondria, disrupts oxidative phosphorylation, catalyzes lipid peroxidation, and ultimately leads to cell death
Though these medications are not currently FDA-approved for PCOS, a couple studies have found that in people with the condition who also have a higher weight, the drugs dont just have a weight-loss effect but can also alleviate PCOS-specific symptoms like cycle abnormalities
10.3389/fphys.2018.01575 175 UthmanL.LiX.BaartscheerA.SchumacherC
GHSR1a dimerization with D1- and D2-like dopamine receptors The interaction between GHSR and dopamine receptors was first hypothesized given the coexpression of these receptors at a number of sites, including a number of brain regions associated with food intake and reward-seeking behaviors (Guan et al., 1997)
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