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No registration trial establishes a weight-loss effect for these combinations, because no such approval pathway has been pursued

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In vivo studies have shown a protective effect when mesenchymal stromal cells engineered to produce GLP-1 were transplanted directly into brain ventricles 21 and the GLP-1 analog exenatide 22 in an ALS mouse model, however there are still limited studies investigating this in ALS

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In clinical trials, participants taking the highest dose of orforglipron lost up to 15% of their body weight by week 72

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