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Pyridoxine (B) in high doses is known to interact with certain drugs: it can reduce the therapeutic efficacy of levodopa by increasing peripheral conversion of levodopa to dopamine (vitamin B speeds up decarboxylation)
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Refrigeration between 2 and 8 degrees Celsius substantially slows this reaction
Apply morning and evening to the under-eye area and eyelids, gently patting it in with circular motions to stimulate microcirculation
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