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In another study, HTY demonstrated hippocampal neurogenesis when administered orally and it activated neurogenesis in the dentate gyrus of normal adult mice, aged wild-type mice, and Btg1-knockout mice modeling accelerated neural aging, HTY-induced neuroprotection involved reduction of oxidative stress markers and apoptotic neuronal death, suppression of microglial activation and pro-inflammatory cytokine release, and functional integration of newly generated neurons into hippocampal memory circuits
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