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It is an intracellular metabolic-enzyme modulator, which is why its research read-outs are things like NAD+ levels and adipocyte gene expression, not how full you feel. That mechanistic distinction is the single most important thing to understand before looking at any dose number
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308 , E1116E1122 (2015)
Its primary role is to serve as a crucial defense mechanism, preventing harmful substances from entering the brain while facilitating the transport of essential nutrients to brain tissue [181]
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