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With these assumptions, 1840 participants randomly assigned to semaglutide or placebo will provide 95% power to confirm superiority of semaglutide for the primary endpoint (change from baseline to week 104 in CDR-SB score)
Other key variables include weight loss efficacy, safety/tolerability, and cardiovascular benefits
Common symptoms include: If your dog exhibits any of these symptoms, particularly if it belongs to an at-risk breed or has had prolonged digestive upset, seek veterinary advice promptly
Always communicate with your healthcare provider about any adverse effects sometimes adjusting the dose or pre-medicating (e.g., with an antiemetic) can make therapy more comfortable
