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Research reveals that senescent cells show upregulation of pro-apoptotic initiators PUMA and BIM while anti-apoptotic guardian BCL-2 is reduced, suggesting these cells are ready to undergo apoptosis but the execution is restrained by the FOXO4-p53 interaction
Diagnosis and Initial Treatment Based on these findings, JC was diagnosed with a severe neuropathy owing to vitamin B 12 deficiency
The inability to utilize fat for energy during stress or fasting can trigger acute metabolic decompensations early in life
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