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He gave the name intrinsic factor to whatever it was in his stomach juice (and vomit) that enabled the absorption of the extrinsic factor, which was later isolated and named Vitamin B12
cyanocobalamin has been reported to precipitate rapid optic nerve damage in individuals with this rare condition
The Arg3 substitution is the critical functional modification because position 3 falls within the IGFBP binding domain, and the charge reversal from acidic glutamate to basic arginine disrupts the electrostatic complementarity required for high-affinity IGFBP interaction
Lyophilization removes water from the peptide material through a controlled freeze-drying process
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