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Another new medication which is currently being studied in clinical trials is TRO19622 (clinicaltrials.gov 2010)
Sleep 2014;37:78593
A 2025 systematic review by Vasireddi and colleagues in HSS Journal screened 544 published papers and identified 36 meeting inclusion criteria 35 preclinical studies and only one human study: an uncontrolled, unblinded, retrospective case series of 12 patients receiving intra-articular BPC-157 for chronic knee pain, in which 7 of 12 (58%) reported self-described relief lasting more than 6 months, with no dose, effect size, or systematically collected adverse events published
Cognitive function, assessed by the MMSE and clock test, and mood, measured by the GDS-15, were evaluated at baseline and study end
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