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Concerning the degradation of extracellular matrix/fibrosis, PHMG and TNF- did not induce any modulation of related biomarkers, even though they have triggered the modulation of inflammatory cytokines (Table 4
55 Epigenetic reprogramming, including DNA methylation and histone modifications, as well as noncoding RNAs (e.g., miRNAs, lncRNAs), further modulates transcriptional landscapes to maintain stemness and reshape the TME, thereby reinforcing resistance to chemotherapy
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