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Over the past two decades, research (predominantly in animal models) has expanded to explore its effects on tendon, muscle, bone, nerve, and vascular tissue

Serious adverse effects are rarely reported, though the absence of large-scale human clinical trials means some uncertainty remains about long-term safety

17 While lifelong annual screening of serum markers is indicated for all patients who undergo MBS, the reality of this occurring is often lowespecially lacking is long-term follow up with a specialized bariatric center

People who undergo surgeries or dental procedures involving nitrous oxide, or who use the drug recreationally