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Thus, neonatal hypertrypsinogenaemia in CFTR carriers, and the enhanced susceptibility to experimental pancreatitis so conveyed, suggests hindrance to CFTR-facilitated apical exocytosis in the acinar cell under conditions of excessive FRA (30)

Therefore, there is a need for well-designed, large-scale, long-term RCTs in healthy adults, in individuals with micronutrient deficiencies, as well as in children an age group undergoing rapid cognitive and brain development

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