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If you dose at 5pm on Monday but 9am on Wednesday, you're preventing your GI tract from adapting to a predictable rhythm
Indeed, most of these data have been obtained in mouse models and it is sometimes difficult to assess in a complete organism whether the effects observed are direct or indirect consequences of DYRK1A or CBS deregulation
The 5 to 8-day half-life means the injection time barely matters
Acta, 1830 (8), 41174129
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