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TM therapy seems able to stabilize neurologic status and prevent neurologic deterioration in these patients, as opposed to the standard initial treatment of choice (20)

This review examines dysregulation of the KP in MDD, emphasizing KP metabolites particularly quinolinic acid and kynurenic acid as biomarkers and mediators of excitotoxicity, neuroinflammation, and oxidative stress, and discusses the therapeutic efficacy of antidepressants that modulate this pathway

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However, there is insufficient evidence indicating that holistic management of glycemia and other risk factors can alleviate the neuropathic pain