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The cell contains millimolar concentrations of GSH (up to 10 mM) that is maintained in this reduced form by a cytosolic NADPHdependent reaction catalysed by glutathione reductase
Additionally, EBI2 is crucial for GC and EF responses that facilitate B cell proliferation and development into PB
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This modification makes the molecule more stable in the gut and allows it to pass through the cell membrane more effectively
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