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During PCOS progression, persistent inflammation also induces mitochondrial dysfunction, uncouples the electron transport chain, and promotes substantial ROS leakage (75)

There are simply too many signals at work in our bodies to ensure full calorie storage At the same time, we observed that key hormones regulating body weight, like the satiety hormone leptin and the hunger hormone ghrelin, were acting in the brain to achieve their effects

Hsieh MJ, et al

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