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Differential structural features in soleus and gastrocnemius of carnitine-treated cancer cachectic rats
This deficiency restricts tissue uptake, leading to decreased accumulation in the heart and skeletal muscle and potentiates increased renal carnitine loss [21, 22] leading to systemic carnitine depletion [23]
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These modifications reduce its affinity for insulin-like growth factor binding proteins, particularly IGFBP-3, which normally sequesters a large majority of circulating native IGF-1
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