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While these trials were not specifically designed to assess joint pain, patients with obesity-related joint pain who achieve significant weight loss through GLP-1 therapy often report improved mobility, reduced need for analgesics, and enhanced ability to engage in physical activitycreating a positive cycle of further weight management and joint health

Toripalimab plus nab-paclitaxel in metastatic or recurrent triple-negative breast cancer: a randomized phase 3 trial

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Real-world observational studies indicate that patients combining these medications typically achieve 1015% body weight reduction over 612 months, with improvements in fasting glucose, insulin levels, and inflammatory markers