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Phillyrin: an adipose triglyceride lipase inhibitor supported by molecular docking, dynamics simulation, and pharmacological validation
However, for patients who clearly have a severe intoxication, naloxone administration should not delay more definitive and evidence-based therapies (e.g., intubation and hemodialysis)
In the oxidative half of the mechanism, Cys63 nucleophilically attacks the nearest sulfide unit in the glutathione disulfide (GSSG) molecule, which creates a mixed disulfide bond (GS-Cys58) and a GS- anion
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