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Biochemical receptors for glutamate fall into two major classes, known as ionotropic glutamate receptors and metabotropic glutamate receptors
A 2022 double-blind, benchmark- and placebo-controlled RCT by Duperray, Sergheraert, and colleagues in the Journal of Cosmetic Dermatology (n=124 Asian women, 12 weeks) found that oral L-cystine plus reduced L-glutathione significantly lightened skin and reduced facial dark spot size at both 6 and 12 weeks versus placebo
Front Physiol 2015
Aim for an IGF-1 SDS (standard deviation score) between +0.5 and +1.5
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